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Hereditary susceptibility in leprosy

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Author:
No author available
Journal Title:
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
Issue:
5
DOI:
10.3760/cma.j.issn.1673-4173.2010.05.017
Key Word:
麻风;疾病遗传易感性;基因;Leprosy;Genetic predisposition to disease;Genes

Abstract´╝Ü Most leprosy-related epidemiological studies are based on the comparison of frequencies of genetic markers in case-control designs using candidate genes. Many susceptibility and resistance genes, such as interleukin (IL)-10 gene, vitamin D receptor (VDR) gene, and NRAMP1 gene, have been newly identified.Genomic scans using family-based designs also have determined some chromosome regions which may be asso ciated with leprosy. With the progress in human genome research, more susceptibility and resistance genes will be found, and these genetic markers will be applied to gene diagnosis and prognosis prediction so as to screen high-risk populations and break the chain of transmission of leprosy.

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