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Genetic mechanism of androgenic alopecia
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1673-4173.2009.02.025
- Key Word:
- 秃发;变异(遗传学);染色体;Alopecia;Variation(genetics);Chromosomes
Abstract： Androgenic alopecia(AGA) is the most common type of hair loss.Its pathogenesis remains unclear.Now AGA is defined as an androgen-dependent disease with characteristic multifactorial inheritance.Androgen receptor gene located on the X chromosome was first found as a susceptibility gene of AGA.Further more,the sex-determining gene located on the Y chromosome and the hairless gene on the autosome gene were also associated with AGA.Recently,scholars have revealed another two susceptibility loci on chromosome 3 q 26 and 20 p11 using genome-wide scan and fine-mapping linkage methods,which may provide further clues to the research of genetic mechanism of AGA.
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