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Toll like receptors and anti-Candida albicans immunity

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Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY

Issue:: 5

DOI:: 10.3760/cma.j.issn.1673-4173.2008.05.019

Key Word:: 念珠菌,白色;Toll样受体;免疫,天然;Candida albicans;Toll-like receptors;Immunity,natural

Abstract： As a member of animal pattern recognition receptor family (PRR), Toll like receptors (TLRs) possess a regulatory effect on both innate and adaptive immunity. Anti-Candida albicans immunity is mainly associated with TLR2 and TLR4. Pathogens can be recognized by TLR2 or TLR4 alone, the dimer of TLR2 or TLR4 with other TLRs, or by the combination of either of them with other pattern recognition receptors, such as Dectin-1 or mannose receptor. It has been evidenced that TLRs on the surface of immune cells can recognize C.albicans, then, mainly through the myeloid differentiation factor 88 (MyD88) -dependant signaling pathway, activate leucocyte chemotaxis, enhance the phagocytosis and candidacidal activity of phagocytes, and trigger the release of related cytokines, which in turn contributes to the defense against C.albicans.

Reference

[1]Bozza S,Rossi G,Bellocchio S,etc.The contribution of the toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo.[J].2004,172(5).
[2]Desa, Lilic,Ian, Gravenor,Neil, Robson,etc.Deregulated production of protective cytokines in response to Candida albicans infection in patients with chronic mucocutaneous candidiasis.[J].2003,71(10).
[3]Del Sero-G,Bacci A,Ricciardi Castagnoli-P,etc.Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo.[J].2000,191(10).
[4]Zelenay S,Lopes Carvalho T,Demengeot J,etc.Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide.[J].2003,197(4).
[5]Montagnoli C.,Bacci A.,Bozza S.,etc.B7\/CD28-Dependent CD4+CD25+ Regulatory T Cells Are Essential Components of the Memory-Protective Immunity to Candida albicans[J].2002.
[6]Adema GJ,Akira S,den-Brok MH,etc.Toll-like receptor 2 controls expansion and function of regulatory T cells.[J].2006,116(2).
[7]Chandrashekhar, Pasare,Ruslan, Medzhitov.Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells.[J].2003,299(5609).
[8]Gessner A,Bode K,Rossner S,etc.TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells.[J].2008,45(1).
[9]Netea MG,Van der Meer JW,van Krieken JH,etc.Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells.[J].2004,172(6).
[10]Hassler S,Herrmann B,Winqvist O,etc.Defect internalization and tyrosine kinase activation in Aire deficient antigen presenting cells exposed to Candida albicans antigens.[J].2006,121(3).
[11]Tada H,Matsumoto T,Shimauchi H,etc.Saccharomyces cerevisiae- and Candida albicans-derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD14-and Toll-like receptor 4-dependent manner[J].2002,46(7).
[12]Arrighi J.-F.,Rebsamen M.,Rousset F.,etc.A Critical Role for p38 Mitogen-Activated Protein Kinase in the Maturation of Human Blood-Derived Dendritic Cells Induced by Lipopolysaccharide, TNF-\u00a0, and Contact Sensitizers[J].2001.
[13]Fenton MJ,Jacobs LE,Verweij PE,etc.Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction.[J].2003,188(2).
[14]Villamon E,Gozalbo D,Roig P,etc.Myeloid differentiation factor 88 (MyD88) is required for murine resistance to Candida albicans and is critically involved in Candida -induced production of cytokines.[J].2004,15(3).
[15]Netea MG,Verschueren I,Kullberg BJ,etc.Role of TLR1 and TLR6 in the host defense against disseminated candidiasis.[J].2008,52(1).
[16]P, Chiani,C, Bromuro,A, Torosantucci.Defective induction of interleukin-12 in human monocytes by germ-tube forms of Candida albicans.[J].2000,68(10).
[17]Lugli E,Mucci A,Colombari B,etc.Biological importance of the two Toll-like receptors, TLR2 and TLR4, in macrophage response to infection with Candida albicans.[J].2005,44(1).
[18]Agrawal A,Gerwitz A,Doughty B,etc.Cutting Edge: different toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos.[J].2003,171(10).
[19]Van Der Meer JW,Kullberg BJ,Verschueren I,etc.The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis.[J].2002,185(10).
[20]Paolo di Francesco,Silvia Bozza,Roberta Gaziano,etc.Dendritic Cells Transport Conidia and Hyphae of Aspergillus fumigatus from the Airways to the Draining Lymph Nodes and Initiate Disparate Th Responses to the Fungus[J].2002,168(3).
[21]Tiffany Horng,Gregory M. Barton,Ruslan Medzhitov.TIRAP: an adapter molecule in the Toll signaling pathway[J].2001,2(9).
[22]Chantal A A, van der Graaf,Mihai G, Netea,Ineke, Verschueren,etc.Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae.[J].2005,73.