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Psoriasis pathogenesis and Toll-like receptors
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1673-4173.2008.02.006
- Key Word:
- 银屑病;免疫;Toll样受体
Abstract： 有越来越多的证据显示银屑病是免疫介导的炎症过程,包括天然免疫和获得性免疫效应机制促进这种慢性皮肤病理过程.Toll样受体是对抗微生物侵入的天然免疫中的关键受体.这些受体不仅表达于外周血细胞也表达于气道上皮细胞和皮肤这些宿主和病原体相互作用部位的免疫细胞,也可能是触发或加重银屑病的微生物感染发生的部位.由于Toll样受体在触发天然免疫和影响获得性免疫中起重要作用,调节Toll样受体的表达可能与银屑病等疾病的病理生理相关.
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