You Position: Home > Paper
Effects of retinoic acid on T lymphocytes
( views:209, downloads:28 )
- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1673-4173.2007.05.015
- Key Word:
- 维甲酸;T淋巴细胞;免疫
Abstract： 维A酸类药物广泛用于治疗各类皮肤病,且其适应证还在不断扩大.近年来越来越多的证据表明,维A酸具有免疫调节作用.首先,维A酸与皮肤免疫有密不可分的联系,其次,维A酸对机体T淋巴细胞的增殖、凋亡、趋化以及Th1/Th2细胞的极化都产生明显及确实的作用,但是维A酸发挥药理学作用涉及的蛋白调控、细胞因子分泌及信号传导的精确机制目前尚不清楚.
- [1]Iwata M,Hirakiyama A,Eshima Y,etc.Retinoic Acid imprints gut-homing specificity on T cells.[J].2004,21(4).
- [2]Z, Szondy,U, Reichert,L, Fésüs.Retinoic acids regulate apoptosis of T lymphocytes through an interplay between RAR and RXR receptors.[J].1998,5(1).
- [3]Kagechika H,Eshima Y,Iwata M.Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.[J].2003,15(8).
- [4]Casey T. Weaver,Xiaowen Jiang,R.Patterson Bucy,etc.Vitamin A Enhances in Vitro Th2 Development Via Retinoid X Receptor Pathway[J].2002,168(9).
- [5]Beáta, Tóth,Katalin, Ludányi,Ildikó, Kiss,etc.Retinoids induce Fas(CD95) ligand cell surface expression via RARgamma and nur77 in T cells.[J].2004,34(3).
- [6]Baeten D,Seta N,Kalsi J,etc.A 588-gene microarray analysis of the peripheral blood mononuclear cells of spondyloarthropathy patients.[J].2002,41(7).
- [7]Yamaguchi T,Maeda Y,Ueda S,etc.Dichotomy of all-trans retinoic acid inducing signals for adult T-cell leukemia[J].2005,19(6).
- [8]J.D.Bos,O.J.deBoer,E.Tibosch,etc.Skin-homing T lymphocytes: detection of cutaneous lymphocyteassociated antigen (CLA) by HECA-452 in normal human skin[J].1993,285(4).
- [9]R, Tóth,E, Szegezdi,U, Reichert,etc.Activation-induced apoptosis and cell surface expression of Fas (CD95) ligand are reciprocally regulated by retinoic acid receptor alpha and gamma and involve nur77 in T cells.[J].2001,31(5).
- [10]Liv M I, Austenaa,Harald, Carlsen,Aase, Ertesvag,etc.Vitamin A status significantly alters nuclear factor-kappaB activity assessed by in vivo imaging.[J].2004,18.
- [11]Rasooly R,Schuster GU,Gregg JP,etc.Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes.[J].2005,175(12).
- [12]H K, Blomhoff.Vitamin A regulates proliferation and apoptosis of human T- and B-cells.[J].2004,32(Pt 6).
- [13]Grenningloh R,Gho A,di Lucia P,etc.Cutting Edge: Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation.[J].2006,176(9).
- [14]Katalin, Ludányi,Zsuzsanna S, Nagy,Magdolna, Alexa,etc.Ligation of RARgamma inhibits proliferation of phytohaemagglutinin-stimulated T-cells via down-regulating JAK3 protein levels.[J].2005,98.
- [15]Hiroshi, Fukasawa,Hiroyuki, Kagechika,Koichi, Shudo.[Retinoid therapy for autoimmune diseases].[J].2006,29(3).