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Pathogenesis of sterile pustulosis
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1673-4173.2007.05.009
- Key Word:
- 脓疱病,无菌性;T淋巴细胞;角蛋白细胞;中性白细胞
Abstract： 无菌性脓疱病的发病机制涉及多种细胞及炎症因子.在外界刺激下,角质形成细胞通过CCL20/CCR6系统、C5a分别趋化T淋巴细胞和中性粒细胞.T淋巴细胞通过穿孔素/颗粒酶B系统和Fas/FasL系统促进表皮内水疱形成,表达CXCL8趋化中性粒细胞、促进角质形成细胞提呈抗原.同时,激活的中性粒细胞可以表达人自细胞DR抗原,刺激T细胞,放大炎症.另外,局部或全身皮肤抗白细胞蛋白酶水平降低也促进脓疱的形成.
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