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Advances on Epidermolytic Hyperkeratosis and Therapeutic Mecbanism with Retinoids

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Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY

Issue:: 6

DOI:: 10.3760/cma.j.issn.1673-4173.2006.06.015

Key Word:: 角化过度症,表皮松解;维A酸类;角蛋白

Abstract：大疱性鱼鳞病是一种少见的常染色体显性遗传性皮肤病,临床以皮肤过度角化为主要表现,并有3种临床亚型.其发病主要由K1、K10和K2e角蛋白基因突变引起,为常染色体显性遗传.临床试验证实,多数患者在局部或系统使用维A酸后,皮肤状态明显改善.就大疱性鱼鳞病的病因、发病机制和维A酸相关作用机制进行综述.

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