Paper - WANFANG MED ONLINE

You Position: Home > Paper

Mechanisms of Ultraviolet Radiation-induced Apoptosis in Keratinocytes

( views:195, downloads:14 )

Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY

Issue:: 6

DOI:: 10.3760/cma.j.issn.1673-4173.2006.06.014

Key Word:: 紫外线;细胞凋亡;信号传导;角蛋白细胞

Abstract：紫外线辐射诱导角质形成细胞凋亡,与多种皮肤病理过程关系密切,已引起人们关注.紫外线可通过诱导活性氧及细胞因子产生DNA损伤和基因表达改变等致角质形成细胞凋亡,此过程有多个信号转导途径参与,其中p53、CD95、Bcl-2、半胱天冬酶、丝裂原活化蛋白激酶介导的信号转导途径起重要作用.

Reference

[1]M, Leverkus,M, Yaar,B A, Gilchrest.Fas/Fas ligand interaction contributes to UV-induced apoptosis in human keratinocytes.[J].1997,232(2).
[2]Assefa Z,Garmyn M,Vantieghem A,etc.Ultraviolet B radiation-induced apoptosis in human keratinocytes: cytosolic activation of procaspase-8 and the role of Bcl-2.[J].2003,540(1/3).
[3]Kitajima Y,Banno Y,Sumi N,etc.Activation of p38 mitogen-activated protein kinase and caspases in UVB-induced apoptosis of human keratinocyte HaCaT cells.[J].1999,112(5).
[4]Adams JM,Cory S.Life-or-death decisions by the Bcl-2 protein family.[J].2001,26(1).
[5]Victor A. Tron,Martin J. Trotter,Liren Tang,etc.p53-Regulated Apoptosis Is Differentiation Dependent in Ultraviolet B-Irradiated Mouse Keratinocytes[J].1998,153(2).
[6]Cheng EH,Wei MC,Weiler S,etc.BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.[J].2001,8(3).
[7]Earnshaw,WC,Martins,LM,Kaufmann,SH.Mammalian caspases: structure, activation, substrates, and functions during apoptosis.[J].1999,68.
[8]Tibudan ShaliniS,Sitailo LeonidA,Denning MitchellF.Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes.[J].2002,277(22).
[9]An, Van Laethem,Sofie, Van Kelst,Saskia, Lippens,etc.Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes.[J].2004,18.
[10]Morita K,Takeda K,Nishitoh H,etc.ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis[J].2001,2(3).
[11]Ferrari D,Rizzuto R,Pinton P,etc.Calcium and apoptosis: facts and hypotheses.[J].2003,22(53).
[12]Peter K.M Kim,Richard Weller,Yun Hua,etc.Ultraviolet irradiation increases FADD protein in apoptotic human keratinocytes[J].2003,302(2).
[13]Bohmer FD,Gulati P,Markova B,etc.UVA inactivates protein tyrosine phosphatases by calpain-mediated degradation[J].2004,5(8).
[14]B. Bang,J. Rygaard,O. Baadsgaard,etc.Increased expression of Fas on human epidermal cells after in vivo exposure to single‐dose ultraviolet (UV) B or long‐wave UVA radiation[J].2002,147(6).
[15]Tenev T,Knebel A,Bohmer FD,etc.Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction.[J].1999,274(37).
[16]Kyriakis JM,Avruch J.Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.[J].2001,81(2).
[17]Oren M.Decision making by p53: life, death and cancer.[J].2003,10(4).
[18]Moll UM,Zaika A,Marchenko ND.Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling.[J].2000,275(21).
[19]Peker S,Hoppe U,Pollet D,etc.Kinetics of DNA strand breaks and protection by antioxidants in UVA- or UVB-irradiated HaCaT keratinocytes using the single cell gel electrophoresis assay.[J].1998,407(2).