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人源抗菌肽LL-37与皮肤病

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Author:: No author available

Journal Title:: FOREIGN MEDICAL SCIENCES(SECTION OF DERMATOLOGY AND VENEREOLOGY)

Issue:: 2

DOI:: 10.3760/cma.j.issn.1673-4173.2004.02.010

Key Word:: 抗生素肽;皮肤疾病

Abstract： LL-37是一种近年来在人体内发现的属于cathelicidins家族的抗菌肽.与防御素相比,他不含有半胱氨酸,无链内二硫键,为具有α螺旋结构的两性分子.他具有广谱的抗菌活性,在先天性免疫中发挥着重要的作用,并广泛参与获得性免疫及一些炎症性疾病的发生发展过程.文中就其分子结构、表达调控、生物学功能及其在皮肤病领域的研究进展作一综述.

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