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一氧化氮、一氧化氮合酶与恶性黑素瘤

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Author:: No author available

Journal Title:: FOREIGN MEDICAL SCIENCES(SECTION OF DERMATOLOGY AND VENEREOLOGY)

Issue:: 1

DOI:: 10.3760/cma.j.issn.1673-4173.2004.01.014

Key Word:: 一氧化氮;一氧化氮合酶;黑色素瘤

Abstract：一氧化氮作为一种重要的信使和效应分子,参与了恶性黑素瘤发生、发展、转移等过程.目前的研究表明一氧化氮合酶在恶性黑素瘤中的表达及活性均有所上调,其合成的一氧化氮在不同的微环境发挥凋亡和抗凋亡、促进转移和抑制转移等多重效应.从分子水平深入理解一氧化氮和一氧化氮合酶在恶性黑素瘤中作用,将为研究其发病机制、治疗带来新的契机与希望.

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