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用博来霉素建立硬皮病动物模型及其应用
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- Author:
- No author available
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1673-4173.2001.06.008
- Key Word:
- 硬皮病;动物模型;博来霉素
Abstract： 硬皮病是一种可累及多个器官和脏器的结缔组织病,其确切的病因和发病机制尚不完全清楚,目前亦无理想的治疗药物和方法.建立合适的硬皮病的动物模型,对于阐明发病机制和遴选治疗药物具有非常重要的意义.文中就应用博来霉素注射实验鼠,建立硬皮病动物模型及其应用情况作了归纳.
- [1]D F, Murrell.A radical proposal for the pathogenesis of scleroderma.[J].1993,28(1).
- [2]N, Hunzelmann,S, Anders,G, Fierlbeck,etc.Systemic scleroderma. Multicenter trial of 1 year of treatment with recombinant interferon gamma.[J].1997,133(5).
- [3]Takagawa S,Katayama I,Nishioka K,etc.Anti-sclerotic effect of transforming growth factor-beta antibody in a mouse model of bleomycin-induced scleroderma.[J].1999,92(1).
- [4]J, Varga,S A, Jimenez.Chemical exposure-induced cutaneous fibrosis. Lessons from 'experiments of nature'.[J].1994,130(1).
- [5]Yamamoto T.,Takagawa S.,Kuroda M.,etc.Effect of interferon-γ on experimental scleroderma induced by bleomycin[J].2000,292(7).
- [6]Denis, M..Neutralization of transforming growth factor-β<sub>1</sub> in a mouse model of immune-induced lung fibrosis.[J].1994,82(4).
- [7]Yamamoto T,Takagawa S,Katayama I,etc.Effect of superoxide dismutase on bleomycin-induced dermal sclerosis: implications for the treatment of systemic sclerosis.[J].1999,113(5).
- [8]Takagawa S,Katayama I,Hamazaki Y,etc.Animal model of sclerotic skin. I: Local injections of bleomycin induce sclerotic skin mimicking scleroderma.[J].1999,112(4).
- [9]Tootell E,Zhang Y,McCormick LL,etc.Anti-TGF-beta treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma.[J].1999,163(10).
- [10]S J, Fishman,G G, Russo.The toxic pseudosclerodermas.[J].1991,30(12).