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尖锐湿疣的免疫学发病机制
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- Author:
- No author available
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1673-4173.2001.05.014
- Key Word:
- 尖锐湿疣;Th1/Th2平衡;克隆漂移
Abstract： 尖锐湿疣患者Th1型细胞因子水平普遍降低,Th2型细胞因子水平相对普遍增高,Th1细胞活动处于弱势,Th2细胞活动相对强势,免疫反应由病毒激发的Th1介导的细胞免疫应答倾向于Th2亚群细胞介导的免疫应答,从而不能有效进行细胞免疫应答清除病毒.尖锐湿疣患者免疫反应向Th2方向漂移可能是人类乳头瘤病毒发生免疫逃逸的一种机制.根据机体Th细胞漂移状况,设法使免疫反应由Th2型向Th1型逆转,调整Th1/Th2平衡,据此设计相应的治疗方案,将可能辅助临床治疗尖锐湿疣.
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