You Position: Home > Paper

The mechanism of autoimmune response and self-maintenance of inflammation in chronic obstructive pulmonary disease

( views:37, downloads:6 )
Author:
No author available
Journal Title:
International Journal of Respiration
Issue:
2
DOI:
10.3760/cma.j.cn131368-20230120-00036
Key Word:
肺疾病,慢性阻塞性;炎症;自身免疫;免疫应答;Pulmonary disease, chronic obstructive;Inflammation;Autoimmunity;Immune response

Abstract: Chronic obstructive pulmonary disease (COPD) has become a worldwide public health challenge due to its high prevalence, disability and mortality.Persistent airway and lung inflammation and the impaired structure of the lung are the main pathological features of COPD.Even after eliminating risk factors, the inflammation of COPD continuously progress, suggesting the existence of an inflammatory self-maintenance mechanism in COPD.Immune responses mediate the occurrence of inflammation in COPD, but the key mechanism is not well understood.This review summarized the mechanisms of adaptive immunity in the pathogenesis of COPD, and proposed that the autoimmune mechanism may be the key to the self-maintenance of chronic inflammation in COPD.Revealing the autoimmune pathogenesis is expected to bring a breakthrough in the early diagnosis and treatment of COPD.

  • This article has no references!
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn