Abstract： Autologous hematopoietic stem cell transplantation (auto-HSCT) is an important therapeutic option for the treatment of lymphoma, and its application in domestic clinical practice is becoming more and more widespread. At present, there is still a gap in the overall standardization and professionalism of auto-HSCT for lymphoma between China and developed countries and regions such as America and Europe, so how to apply auto-HSCT in a standardized and rational manner is still a problem faced by domestic clinicians. Based on the experience of major auto-HSCT centers in China and related research progress at home and abroad, the guiding principles are developed by the Autologous Hematopoietic Stem Cell Transplantation Working Group of Chinese Society of Clinical Oncology (CSCO), which summarize the indications for auto-HSCT, mobilization and collection of stem cells, freezing and resuscitation of stem cells, transplantation conditioning, transplantation-related complications, and nursing care during transplantation. It aims to guide clinicians to better apply auto-HSCT for the treatment of lymphoma and bring maximum benefit to patients.