Efficacy analysis of whole brain confomal intensity-modulated radiation therapy combined with synchronous dosage for treatment of brain metastases

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Author:
ZHANG Xia-qin(Department of Radiation Oncology,Shanxi Cancer Hospital,Taiyuan 030013,China)
LI Hong-wei(Department of Radiation Oncology,Shanxi Cancer Hospital,Taiyuan 030013,China)
JIA Su-fang(Department of Radiation Oncology,Shanxi Cancer Hospital,Taiyuan 030013,China)
LI Zheng-ran(Department of Radiation Oncology,Shanxi Cancer Hospital,Taiyuan 030013,China)
GUO Ru-yuan(Department of Radiation Oncology,Shanxi Cancer Hospital,Taiyuan 030013,China)
SONG Xin(Department of Radiation Oncology,Shanxi Cancer Hospital,Taiyuan 030013,China)
Journal Title:
Cancer Research and Clinic
Issue:
Volume 24, Issue 08, 2012
DOI:
10.3760/cma.j.issn.1006-9801.2012.08.014
Key Word:
Brain metastases; Radiotherapy, intensity-modulated; Whole brain radiotherapy;Simultaneous integrated boost

Abstract: Objective To discuss dosimetric advantage,compliance,efficacy and prognostic factors of whole brain conformal intensity-modulated radiotherapy ( IMRT ) combined with synchronous dosage for treatment of brain metastases.Methods Forty-one patients with metastatic tumor to the brain were confirmed by computed tomography (CT) or magnetic resonance imaging (MRI).They received whole brain irradiation and simultaneous integrated boost to bulky metastases by IMRT.Gross tumor volume(GTV) DT 4994-6990 cGy/ 22-30 fractions/4.4-6.0 weeks,whole brain DT 3990-5000 cGy/22-30 fractions/4.4-6.0 weeks.Results The median follow-up time was 6.4 months.The overall response rate,the median survival time and the overall survival at 1 year were 65.8 %,8 months,24.4 %.The brain-stem,spinalcord,lens,opticnerves were in the limited dose.In 21 patients,radioactive brain edema was happened,the rest did not appear early and late radiation reaction.Conclusion Whole brain irradiation using simultaneous integrated boost to bulky lesion by IMRT show an improvement in dose distribution and significant effect to patients with brain metastases.The therapy is well-tolerated and effective.

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