Efficacy analysis of whole brain confomal intensity-modulated radiation therapy combined with synchronous dosage for treatment of brain metastases
- Author:
- No author available
- Journal Title:
- Cancer Research and Clinic
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1006-9801.2012.08.014
- Key Word:
- 脑转移瘤;放射疗法,调强适形;全脑放疗;同步加量;Brain metastases;Radiotherapy,intensity-modulated;Whole brain radiotherapy;Simultaneous integrated boost
Abstract： Objective To discuss dosimetric advantage,compliance,efficacy and prognostic factors of whole brain conformal intensity-modulated radiotherapy ( IMRT ) combined with synchronous dosage for treatment of brain metastases.Methods Forty-one patients with metastatic tumor to the brain were confirmed by computed tomography (CT) or magnetic resonance imaging (MRI).They received whole brain irradiation and simultaneous integrated boost to bulky metastases by IMRT.Gross tumor volume(GTV) DT 4994-6990 cGy/ 22-30 fractions/4.4-6.0 weeks,whole brain DT 3990-5000 cGy/22-30 fractions/4.4-6.0 weeks.Results The median follow-up time was 6.4 months.The overall response rate,the median survival time and the overall survival at 1 year were 65.8 ％,8 months,24.4 ％.The brain-stem,spinalcord,lens,opticnerves were in the limited dose.In 21 patients,radioactive brain edema was happened,the rest did not appear early and late radiation reaction.Conclusion Whole brain irradiation using simultaneous integrated boost to bulky lesion by IMRT show an improvement in dose distribution and significant effect to patients with brain metastases.The therapy is well-tolerated and effective.
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