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Relationship between single nucleotide polymorphism of urokinase-type plasminogen activator gene and tongue carcinoma
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- Author:
- No author available
- Journal Title:
- Cancer Research and Clinic
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1006-9801.2012.08.013
- Key Word:
- 舌肿瘤;尿纤溶酶原激活物;多态性,单核苷酸;Tongue neoplasms;Urinary plasminogen activator;Polymorphism,single nucleotide
Abstract： Objective To determine association between tongue carcinoma and polymorphism of urokinase-type plasminogen activator (PLAU) gene.Methods PLAU genotypes of 97 patients with tongue carcinoma and 91 health controls were examined by the PCR-RFLP method.Statistical analyses included a chi-square test for homogeneity and logistic regression analysis.Results The polymorphism in PLAU gene was rs2227564 C/T.Logistic analyses indicated that compared with CT and TT genotypes,CC genotype was risk factor for development of tongue carcinoma (adjusted OR =1.281,95 ％ CI 1.098-2.577,P =0.037).Conclusion PLAU polymorphism may be associated with development of tongue carcinoma.
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