Low expression of cystic fibrosis transmembrane conductance regulator gene allele IVS8-5T may be associated with decreased prostate cancer risk

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QIAO Di(Department of Urology,Jiangsu Province Geriatric Institute,Nanjing 210024,China)
HUA Li-xin()
YI Long()
NI Li-gang(Department of Urology,Jiangsu Province Geriatric Institute,Nanjing 210024,China)
DING Yi(Department of Urology,Jiangsu Province Geriatric Institute,Nanjing 210024,China)
ZHANG Shi-ge(Department of Urology,Jiangsu Province Geriatric Institute,Nanjing 210024,China)
WU Ye(Department of Urology,Jiangsu Province Geriatric Institute,Nanjing 210024,China)
WANG Jiu-lin(Department of Urology,Jiangsu Province Geriatric Institute,Nanjing 210024,China)
WU Hong-fei()
Journal Title:
Cancer Research and Clinic
Volume 24, Issue 08, 2012
Key Word:
Prostate neoplasms; CFTR; Polymorphism

Abstract: Objective To investigate the association between functional polymorphism IVS8-poly (T) in cystic fibrosis transmembrane conductance regulator (CFTR) gene and prostate cancer risk.Methods A population-based case-control study was conducted including 230 prostate cancer patients and 230 agematched controls.PCR-STRP was used to analysis the IVS8-poly (T) tract in CFTR gene.Results The prevalences of the low expression allele,the IVS8-5T,in prostate cancer patients and controls were 1.52 % (7/460) and 5.22 % (24/460),respectively (x2 =12.489,P =0.002).Logistic regression analysis confirmed the 5T/7T genotype was in protective association with prostate cancer risk (OR =0.232,P =0.003,95 % CI0.090-0.599).Conclusion The low expression CFTR IVS8-5T allele contributes to a reduced risk of prostate cancer in Chinese Han population,and may be a protective factor against prostate cancer.

  • [1]Lichtenstein P,Holm NV,Verkasalo PK,et al.Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden,Denmark,and Finland.N Engl J Med,2000,343:78-85.
  • [2]宋恕平.前列腺癌的诊断与治疗.肿瘤研究与临床,2008,20:361-363.
  • [3]Hayes RB.Gene-environment interrelations in prostate cancer.Epidemiol Rev,2001,23:163-167.
  • [4]杨毅,郝利楠,米振国,等.吸烟与前列腺癌发病关系的Meta分析.肿瘤研究与临床,2007,19:286-288.
  • [5]Rowe SM,Miller S,Sorscher EJ.Cystic fibrosis.N Engl J Med,2005,352:1992-2001.
  • [6]Neglia JP,FitzSimmons SC,Maisonneuve P,et al.The risk of cancer among patients with cystic fibrosis.Cystic Fibrosis and Cancer Study Group,N Engl J Med,1995,332:494-499.
  • [7]Maisonneuve P,FitzSimmons SC,Neglia JP,et al.Cancer risk in nontransplanted and transplanted cystic fibrosis patients:a 10-year study.J Natl Cancer Inst,2003,95:381-387.
  • [8]Johannesson M,Askling J,Montgomery SM,et al.Cancer risk among patients with cystic fibrosis and their first-degree relatives.Int J Cancer,2009,125:2953-2956.
  • [9]Walsh PS,.Metzger DA,Higuchi R.Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material.Biotechniques,1991,10:506-513.
  • [10]Chillón M,Casals T,Mercier B,et al.Mutations in the cystic fibrosis gene in patients with congenital absence of the vas deferens.N Engl J Med,1995,332:1475-1480.
  • [11]Shi YY,He L.SHEsis,a powerful software platform for analyses of linkage disequilibrium,haplotype construction,and genetic association at polymorphism loci.Cell Res,2005,15:97-98.
  • [12]Wu CC,Alper OM,Lu JF,et al.Mutation spectrum of the CFTR gene in Taiwanese patients with congenital bilateral absence of the vas deferens.Hum Reprod,2005,20:2470-2475.
  • [13]Nam MH,Hijikata M,Tuan LA,et al.Variations of the CFTR gene in thc Hanoi-Vietnamese.Am J Med Genet A,2005,136:249-253.
  • [14]Malats N,Casals T,Porta M,et al.Cystic fibrosis transmembrane regulator (CFTR) DeltaF508 mutation and 5T allele in patients with chronic pancreatitis and exocrine pancreatic cancer.PANKRAS ⅡStudy Group.Gut,2001,48:70-74.
  • [15]Matsubayashi H,Fukushima N,Sato N,et al.Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer.Cancer Biol Ther,2003,2:652-655.
  • [16]McWilliams RR,Petersen GM,Rabe KG,et al.Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations and risk for pancreatic adenocarcinoma.Cancer,2010,116:203-209.
  • [17]Pan J,Bear C,Farragher S,et al.Cystic fibrosis transmembrane conductance regulator modulates neurosecretory function in pulmonary neuroendocrine cell-related tumor cell line models.Am J Respir Cell Mal Biol,2002,27:553-560.
  • [18]Son JW,Kim YJ,Cho HM,et al.Promoter hypermethylation of the CFTR gene and clinical/pathological features associated with nonsmall cell lung cancer.Respirology,2011,16:1203-1209.
  • [19]Benlloch M,Ortega A,Ferrer P,et al.Acceleration of glatathione efflux and inhibition of gamma-glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity.J Biol Chem,2005,280:6950-6959.
  • [20]Lemonnier L,Shuba Y,Crepin A,et al.Bcl-2-dependent modulation of swelling-activated Cl-current and ClC-3 expression in human prostate cancer epithelial cells.Cancer Res,2004,64:4841-4848.
  • [21]Lader AS,Prat AG,Jackson GR Jr,et al.Increased circulating levels of plasma ATP in cystic fibrosis patients.Clin Physiol,2000,20:348-353.
  • [22]Humez S,Monet M,van Coppenolle F,et al.The role of intracellular pH in cell growth arrest induced by ATP.Am J Physiol Cell Physiol,2004,287:C1733-C1746.
  • [23]Hiraoka K,Miyazaki H,Niisato N,et al.Chloride ion modulates cell proliferation of human androgen-independent prostatic cancer cell.Cell Physiol Biochem,2010,25:379-388.
  • [24]Davis GC,Kong Y,Paige M,et al.Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografis.Bioorg Med Chem,2012,20:2180-2188.
  • [25]Yildirim S,Altun S,Gumushan H,et al.Voltage-gated sodium channel activity promotes prostate cancer metastasis in vivo.Cancer Lett.2012,323:58-61.
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