Expression and clinicopathological significance of ADAM17 mRNA in esophageal squamous cell carcinoma
- Author:
- No author available
- Journal Title:
- Cancer Research and Clinic
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1006-9801.2012.07.004
- Key Word:
- 食管肿瘤;ADAM17 mRNA;反转录聚合酶链反应;Esophageal neoplasms;ADAM17 mRNA;Reverse transcriprase polymerase chain reaction
Abstract： Objective To investigate the clinicopathologic significance of a disintegrin and metalloproteinase 17(ADAM 17) mRNA in esophageal squamous cell carcinoma (ESCC),and to evaluate its relation to clinicopathological features. Methods The expression of ADAM17 mRNA in 50 ESCC and 50 normal esophageal tissues were detected by RT-PCR. Results The mRNA expression of ADAM17 in 50 ESCC and 50 normal esophageal tissues were 0.937±0.241 and 0.225±0.077,respectively.The expression of ADAM17 mRNA in the ESCC was much higher than in normal esophageal tissues (t=-19.899,P＜0.01).The expression of ADAM 17 mRNA was positively correlated with lymph node metastasis(t=-4.703,P＜0.01 ) and TNM staging (t=-2.652,P＜0.05).There were no correlation between the expression of ADAM17 mRNA and sex,age and histological grade (t=0.299,-0.907,-3.163,all P＞0.05).Conclusion ADAM17 mRNA was higherly express in ESCC than in normal esophageal tissues and may play an important role in the development,invasion and metastasis of ESCC.It may be used as a prognostic factor.
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