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Expressions of leptin and lipoprotein α in esophageal squamous cell carcinoma and their clinical significance

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Author:: No author available

Journal Title:: Cancer Research and Clinic

Issue:: 7

DOI:: 10.3760/cma.j.issn.1006-9801.2012.07.003

Key Word:: 食管肿瘤;癌,鳞状细胞;血脂;瘦素;Esophageal neoplasms;Carcinoma,spuamous cell;Lipids;Leptin

Abstract： Objective to investigate serum leptin concentration and lipdid levels in patients with esophageal squamous cell carcinoma and their clinical significance. Methods Blood samples were collected from 47 patients with esophageal cancer, 20 healthy control subjects. Serum leptin was measured by ELISA and serum lipids was measured by biochemistry auto-analyzer. Results The serum leptin concentration and LP α levels in patients group were significantly higher than those in control group[(13.09±5.94) ng/ml vs (7.584±4.15) ng/ml,(216.50±752.52) ng/ml vs(87.85±10.73) mg/L](P=0.001).However,the TG concentration was significantly lower than control group [(1.23±0.46) mmol/L vs (1.58±0.07) mmol/L]( P=0.001 ).Multiple logistic regression analysis revealed statistically significant association between serum leptin levels and esophageal squamous cell carcinoma incident (ORLeptm =1.442,95％ CI 1.094-1.848). Conclusion The increased serum leptin levels maybe the risk factors of esophageal cancer, elevated LP α levels in patients might be a compensatory reactions.

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