Study on cisplatin combination with pemetrexed disodium in the therapy for malignant pleural mesothelioma
- Author:
- No author available
- Journal Title:
- Cancer Research and Clinic
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1006-9801.2011.11.005
- Key Word:
- 恶性胸膜间皮瘤;培美曲塞;顺铂;药物疗法,联合;无进展生存期;生存期;Malignant pleural mesothelioma;Pemetrexed;Cisplatin;Drug therapy,combination;Progression-free survival;Survival rate
Abstract： Objective To explore the clinical efficacy of ALIMTA (pemetrexed disodium) plus cisplatin.Methods Patients with malignant mesothelioma were allocated to two treatment groups envelope:pemetrexed plus cisplatin (PEM-group) or cisplatin alone (DDP-group).Results A total of 64 patients were randomly assigned and evaluated.The number of patients in PEM- and DDP-group had a significant pathologic complete response were (56.25 ％ vs 21.88 ％,x2 =7.943,P ＜0.05).Progression-free survival was significantly higher in PEM-group (P ＜0.05),and 2-year survival rate was lower in DDP-group (P ＜0.05).Conclusion Pemetrexed elicit significant tumor response and delays disease progression compared with DDP alone in patients with advanced MPM.Improvement in OS is seen in this study.
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