Association of serum levels of HDL-C,LDL-C with lymphatic metastasis and clinical stage in gastric cancer
- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1006-9801.2011.07.004
- Key Word:
- 胃癌;HDL-C;淋巴结转移;Gastric carcinoma;HDL-C;Lymphatic metastasis
Abstract： Objective To investigate the correlation of serum levels of HDL-C,LDL-C with clinical stage and lynlphatic metastasis in gastric malignant tumors. Methods Preoperative serum levels of HDL-C and LDL-C were retrospectively analyzed in 114 gastric cancer patients who were diagnosed by pathology.Results Serum, levels of HDL-C showed a remarkable correlation with tumor differentiation,lymphatic metastasis and the diameter of tumor in gastric cancer (P＜0.05).The lower serum levels of HDL-C were significantly observed in gastric cancer patients with TNM Ⅲ and IV stage,compared with those with TNM Ⅰ and Ⅱ stage (P＜0.05). Conclusion Preoperative serum levels of HDL-C might be a useful biomarker of lymphatic metastasis and advanced stage of gastric cancer.
- [1]缪云翔,王晶敏.血清总胆固醇及高密度脂蛋白与胃癌的相关性分析[J].2008,28(5).
- [2]Branchi A,Sommariva D,Fiorenza AM.Serum lipoprotein profile in patients with cancer. A comparison with non-cancer subjects.[J].2000,30(3).
- [3]Guo E,Chen L,Xie Q,etc.Serum HDL-C as a potential biomarker for nodal stages in gastric cancer.[J].2007,14(9).
- [4]Sandra Dessì,B. Batetta,D. Pulisci,etc.Cholesterol content in tumor tissues is inversely associated with high-density lipoprotein cholesterol in serum in patients with gastrointestinal cancer[J].1994,73(2).
- [5]李白云.胃癌、食管癌患者血清和组织中低密度脂蛋白及胆固醇含量的测定[J].1993,(2).
- [6]Ruggieri E,D'Attoma B,Caruso MG,etc.Serum lipid profile in colorectal cancer patients with and without synchronous distant metastases.[J].2005,68(4).
- [7]M L, Knapp,S, al-Sheibani,P G, Riches.Alterations of serum lipids in breast cancer: effects of disease activity, treatment, and hormonal factors.[J].1991,37.
- [8]E, Bayerd?rffer,G A, Mannes,W O, Richter,etc.Decreased high-density lipoprotein cholesterol and increased low-density cholesterol levels in patients with colorectal adenomas.[J].1993,118(7).