Identification of nodules of altered hepatocytes from focal nodular hyperplasia,with comparison to hepatocellular adenoma
- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1006-9801.2010.02.004
- Key Word:
- 变异肝细胞结节;局灶性结节状增生;微血管密度;腺瘤;肝细胞;Nodule of altered hepatocytes;Focal nodular hyperplasia;Microvascular density;Adenoma,liver cell
Abstract： Objective Focal nodular hyperplasia(FNH) is composed of multiple hyperplastic liver cell nodules,but its pathogenesis has not been elucidated. Foci (FAH) or nodules of altered hepatocytes (NAH) are precursors of hepatocellular adenoma (HCA) and carcinoma.This study aimed at identifying FAH and NAH from FNH and evaluating their role in FNH development.Methods 6 FNH lesions from 5 patients and 10 HCA from 9 patients were examined histologically,and expression levels of CD_(34) cytokeratin 19(CKl9) and Ki-67 antigen were demonstrated immunohistochemicailly.Proliferative activity was evaluated by Ki-67 antigen-labeling indices(Ki-67 LI).Results Multiple FAH and NAH were identified in all of the 6 FNH lesions. Whiie micmvasculatures were demonstrated by CD_(34) immunoreactivity in both HCA and FNH,their density and distribution were different in these two lesions,being diffuse in HCA and focal or nodular,mainly within NAH.CKl9 expression Was found in FNH,localized in ductal and ductular cells,but not within NAH and HCA.Average Ki.67 LI of 73 NAH(2.8%) was shown to be higher than that of the whole FNH lesions (0.6%),and had no statistieal difference comparable to that of HCA(1.8%).Conclusion Muhiple NAH are present in all classical FNH lesions.Unlike the surrounding parenchyma,NAH lesions are more proliferative and equipped with CD_(34)-positive microvasculatures as in HCA.
- [1]初霞,苏勤,巩丽,等.慢性乙型肝炎和肝硬化组织中变异肝细胞结节的克隆性[J].2005,(8).
- [2]巩丽,张宏图,张伟,等.克隆性分析技术在肝脏局灶性结节性增生诊断中的应用[J].2006,(6).
- [3]Li Gong,QIN Su,Wei ZHANG,etc.Liver cell adenoma: A case report with clonal analysis and literature review[J].2006,(13).
- [4]Fiorentino M,D'Errico A,Grigioni WF,etc.Endothelial cell differentiation in hepatocellular adenomas: implications for histopathological diagnosis.[J].2004,41(2).
- [5]V Paradis,A Laurent,J Flejou,etc.Evidence for the polyclonal nature of focal nodular hyperplasia of the liver by the study of X-chromosome inactivation[J].1997,26(4).
- [6]Su Q,Bannasch P,Haertel T.Significance of hepatic preneoplasia in risk identification and early detection of neoplasia.[J].2003,31(1).
- [7]Su Q,Bannasch P.Relevance of hepatic preneoplasia for human hepatocarcinogenesis.[J].2003,31(1).
- [8]Ian R. Wanless,Carolyn Mawdsley,Ronald Adams.On the pathogenesis of focal nodular hyperplasia of the liver[J].1985,5(6).
- [9]Jain D,Bifulco CB,Robert ME,etc.Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance.[J].2008,39(9).
- [10]P, Kerlin,G L, Davis,D B, McGill,etc.Hepatic adenoma and focal nodular hyperplasia: clinical, pathologic, and radiologic features.[J].1983,84.
- [11]C, Zhu,G, Bao,N, Wang.Cell mechanics: mechanical response, cell adhesion, and molecular deformation.[J].2000,2.
- [12]Benner A,Su Q,Hofmann WJ,etc.Human hepatic preneoplasia: phenotypes and proliferation kinetics of foci and nodules of altered hepatocytes and their relationship to liver cell dysplasia.[J].1997,431(6).
- [13]Teng XY,Gong L,Cai YR.Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma.[J].2009,15(37).
- [14]N, Tanigawa,H, Amaya,M, Matsumura,etc.Tumor angiogenesis and mode of metastasis in patients with colorectal cancer.[J].1997,57.