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Analysis of epidermal growth factor receptor(EGFR) mutations in non-small-cell lung cancer patients in Fujian province

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Author:
No author available
Journal Title:
CANCER RESEARCH AND CLINIC
Issue:
8
DOI:
10.3760/cma.j.issn.1006-9801.2008.08.003
Key Word:
癌;非小细胞肺;受体;表皮生长因子;基因;突变;Carcinoma,non-small-ceu lung;Receptor,epidermal growth factor,Gene;Mutation

Abstract: Objective To analyze the epidemud growth factor receptor(EGFR)mutations in NSCLC patients in Fujian province.Methods Fresh specimens of lung cancer and corresponding normal lung tissue were collected from 50 cases of NSCLC patients.After DNA extraction,nested polymerase chain reaction (nested PCR)and direct deoxyribonucleic acid(DNA)sequencing were used to analyze EGFR gene mutations in NSCLC patients.Results EGFR mutations in tumors were identified from 13 of 50(26%)patients,including 10 cages of in-frame deletion in exon 19 and 3 cases of amino acid substitution in exon 21.Conclusion The mjor type of EGFR mutation in NSCLC patients in Fujian is in-frame deletion in exon 19.

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