You Position: Home > Paper
Clinical observation of gefitinib in treatment of female patients with adenocarcinoma of lung
( views:264, downloads:4 )
- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1006-9801.2007.12.005
- Key Word:
- 肺肿瘤;女(雌)性;药物疗法
Abstract： 目的 观察吉非替尼治疗化疗失败的晚期女性肺腺癌的疗效及副作用.方法 吉非替尼250mg,口服,1次/d,连续服用至疾病进展或出现不可耐受的不良反应.患者分别在治疗后1个月及随后每2个月评价.结果 在可评价疗效的27例患者中,完全缓解(CR)1例(3.7%),部分缓解(PR)11例(40.8%),疾病稳定(SD)10例(37.0%),疾病进展(PD)5例(18.5%),总有效(CR+PR)率44.5%,95%可信区间为29%～68%;疾病控制率81.5%,95%可信区间为62%～94%;症状缓解率为80.0%;平均肿瘤进展时间(TTP)为7.2个月.不良反应主要为轻度的皮疹与腹泻.结论 吉非替尼治疗化疗失败的晚期女性肺腺癌疗效显著,副作用轻微.
- [1]Masaki, Tokumo,Shinichi, Toyooka,Katsuyuki, Kiura,etc.The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers.[J].2005,11(3).
- [2].中国恶性肿瘤死亡率20年变化趋势图[J].1997,(6).
- [3]Rodrigues Pereira J,Tan EH,Archer V,etc.Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer).[J].2005,366(9496).
- [4]Kanazawa M,Nagata M,Uchida Y,etc.Gefitinib for non-small-cell lung cancer patients with epidermal growth factor receptor gene mutations screened by peptide nucleic acid-locked nucleic acid PCR clamp.[J].2006,95(11).
- [5]Moehren G,Demin OV,Hoek JB,etc.Quantification of short term signaling by the epidermal growth factor receptor.[J].1999,274(42).