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Expression of heparanase protein and its relationship with prognosis in transitional cell carcinoma of bladder
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1006-9801.2007.08.005
- Key Word:
- 膀胱肿瘤;肝素酶;预后;免疫组织化学
Abstract： 目的 探讨乙酰肝素酶(HPA)在膀胱移行细胞癌组织中的表达及其对膀胱癌预后判断的意义.方法 应用免疫组化法,分别对80份膀胱癌组织中HPA的表达和微血管密度(MVD)进行检测.20份非肿瘤膀胱组织作为对照.结果 80份膀胱癌组织中HPA阳性率57.5%(n=46),非癌膀胱组织中HPA表达均为阴性,两组差异有统计学意义(P＜0.01).HPA表达阳性率随着膀胱癌分期、分级的增高及淋巴结转移而升高(P＜0.05).膀胱癌组织中HPA阳性组MVD值为45.24±9.95,显著高于阴性组(34.0±10.34)(P＜0.01).HPA表达阳性组的膀胱癌患者的2、3、5年生存率低于阴性组(分别P＜0.05,P＜O.05和P＜0.01),COX模型多因素分析显示HPA是膀胱癌的一种独立预后不良因子.结论 HPA的表达与膀胱移行细胞癌的临床病理特征和新血管生成相关,是膀胱癌一种新的独立预后不良因子.
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