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Clinical effect of early postoperation adjuvant intraperitoneal chemotherapy of locally advanced gastrie cancer
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1006-9801.2007.06.005
- Key Word:
- 胃肿瘤;抗肿瘤联合化疗;腹腔灌洗
Abstract： 目的 观察根治术后早期经皮腹腔置管腔内化疗对胃癌术后患者生存情况的影响.方法 40例Ⅲ期以上胃癌根治术后患者分为治疗组和对照组,每组20例.治疗组在术后1个月内先行经皮腹腔保留置管,腹腔内顺铂80 mg、氟脲苷1 g灌注2～3次,随后行以FOLFOX4为主的全身化疗.对照组在术后仅行全身化疗.结果 治疗组1年无病生存率为60%,较对照组(25%)增高(P＜0.05);中位无病生存、总生存、腹盆腔复发转移出现时间较对照组延长,1年总生存率为85%,较对照组(70%)略增高,但差异无统计学意义(P＞0.05).治疗组化疗不良反应与对照组无明显差异,未出现与腹腔灌注治疗相关的出血、感染、化疗药外漏、胃肠穿孔和发热等并发症.结论 胃癌根治术后早期腹腔置管腔内化疗可提高患者1年无病生存率,延长生存期,并发症少,耐受性好,具有一定的实用性及可行性,但需进一步扩大临床验证.
- [1]Klempnauer J,Piso P,Schmidt U,etc.Cytoreductive surgery and intraperitoneal chemotherapy for pseudomyxoma peritonei.[J].2005,20(2).
- [2]Glehen O,Gilly FN,Mohamed F.Peritoneal carcinomatosis from digestive tract cancer: new management by cytoreductive surgery and intraperitoneal chemohyperthermia.[J].2004,5(4).
- [3]吴志扬,张明,胡以则,等.术后腹腔化疗改善胃肠癌预后的疗效观察[J].1997,(4).
- [4]Sugarbaker PH.Cytoreductive surgery and peri-operative intraperitoneal chemotherapy as a curative approach to pseudomyxoma peritonei syndrome.[J].2001,27(3).
- [5]C H, Yoo,S H, Noh,D W, Shin,etc.Recurrence following curative resection for gastric carcinoma.[J].2000,87(2).
- [6]宋水勤,张国楠,吴艳丽,等.卵巢恶性肿瘤术后腹腔化疗-单次直接腹腔穿刺法[J].1997,(1).
- [7]W, Yu,I, Whang,A, Averbach,etc.Morbidity and mortality of early postoperative intraperitoneal chemotherapy as adjuvant therapy for gastric cancer.[J].1998,64(11).