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Antiproliferation and induction differentiation of rosiglitazone in human gastric carcinoma transplanted into nude mice
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1006-9801.2007.06.002
- Key Word:
- 胃肿瘤;罗格列酮;细胞增生;酶诱导
Abstract： 目的 研究罗格列酮(ROS)对人胃癌MGC-803细胞裸小鼠移植瘤的抗增生和诱导分化作用,初步探讨其可能的机制.方法 随机分为未用药组(B组)、全反式维甲酸(ATRA)组(C组)、D1组(ROS 25mg/kg)、D2组(ROS 50mg/kg)、D3组(ROS 100mg/kg).用药后,观察移植瘤体积变化及计算抑瘤率;检测细胞周期及胃黏蛋白(Mucin 5AC).结果 ROS能缩小瘤体体积,B组与未用药组比较差异有统计学意义(P＜0.01),且呈剂量依赖关系,D1、D2、D3组和C组差异无统计学意义(P＞0.05);ROS使瘤细胞显示分化细胞的特征:细胞被阻滞于G0/G1期,S期细胞减少;Mucin 5AC表达增强.结论 ROS有一定的抑瘤作用,呈剂量依赖关系;ROS诱导胃癌移植瘤细胞分化,其机制可能是通过抑制癌细胞从G1期向S期过渡、降低细胞的增生能力、调控胃癌增生、分化相关基因表达实现的.
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