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The expression of VEGF,COX2 and mPGES mRNA in colon cancer
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1006-9801.2007.04.004
- Key Word:
- 结肠肿瘤;血管内皮生长因子;前列腺素E类
Abstract： 目的 通过研究血管内皮生长因子(VEGF)、COX-2和膜相关前列腺素E合成酶(mPGES)在结肠癌中的表达,探讨VEGF、COX-2和mPGES与结肠癌的关系.方法 采用实时荧光定量RT-PCR法,对32例结肠癌组织及其相应癌旁组织中VEGF、COX-2和mPGES mRNA的表达进行了研究.结果 32例癌组织中,VEGF121表达无变化.VEGF165高表达19例(59.3%);COX-2高表达20例(62.5%);mPGES高表达24例(75%).32例癌旁组织中,VEGF高表达6例(18.7%);COX-2高表达5例(15.6%);mPGES高表达9例(28.12%).结论 VEGFl65、COX-2和mPGES与结肠癌的发生相关.COX-2和mPGES在结肠癌组织中上调程度存在差异,提示COX-2和mPGES这两种诱导型酶在调节机制上可能存在差异.
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