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Expression of P450 aromatase in endometrial carcinoma
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1006-9801.2007.03.005
- Key Word:
- 子宫内膜肿瘤;子宫内膜增生;免疫酶技术;免疫组织化学;芳香化酶P450
Abstract： 目的 探讨芳香化酶P450(P450arom)在正常子宫内膜、增生子宫内膜以及子宫内膜癌中的表达,探讨P450arom在子宫内膜癌发生和发展中的作用.方法 实验分成三组:子宫内膜腺癌组标本50份、子宫内膜增生症组内膜标本27份、正常子宫内膜组标本20份.采用免疫组化(ABC)方法分别测定3组标本中P450arom的表达.结果 P450arom在子宫内膜癌、子宫内膜增生症内膜腺上皮中均阳性表达,两者比较差异无统计学意义(P＞0.05).P450arom在正常子宫内膜中无表达.P450arom在子宫内膜腺癌癌组织间质细胞中表达21例(42%),间质细胞阳性表达与手术病理期别及病理分级密切相关,而与肌层浸润深度、淋巴结转移无关.结论 P450arom在子宫内膜癌发生、发展中起重要作用.子宫内膜腺癌癌组织间质细胞P450arom表达与肿瘤发展及预后密切相关.
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