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Effect of celecoxib on endometrial carcinoma cell proliferation and expression of COX-2 mRNA
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1006-9801.2007.03.002
- Key Word:
- 塞来昔布;子宫内膜肿瘤;细胞增殖
Abstract： 目的 探讨塞来昔布对子宫内膜癌细胞HEC-1-B的作用及对COX-2 mRNA表达的影响.方法 采用细胞培养、MTT试验研究不同浓度的塞来昔布对人类子宫内膜癌细胞HEC-1-B生长的抑制作用,通过RT-PCR法检测塞来昔布作用后COX-2 mRNA表达的变化.结果 塞来昔布能够有效地抑制HEC-1-B细胞的生长,并呈一定的剂量和时间依赖关系,同时能够抑制其COX-2 mRNA表达,20μmol/L和50μmol/L塞来昔布对COX-2 mRNA表达的抑制率分别为25.92%和50.81%.结论 塞来昔布可能是通过降低COX-2 mRNA的表达而抑制子宫内膜癌细胞的生长.
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