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Combination chemotherapy with oxaliplatin and capecitabine as a second line chemotherapy for 24 patients with advanced gastric cancer
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1006-9801.2007.01.005
- Key Word:
- 胃肿瘤;抗肿瘤联合化疗;奥沙利铂;卡培他滨
Abstract： 目的 观察奥沙利铂(L-OHP)联合卡培他滨(商品名:希罗达)二线治疗晚期胃癌的临床疗效和毒副作用.方法 晚期复治性胃癌26例,L-OHP130 mg/m2,加入5%葡萄糖注射液500 ml中静脉滴注2 h,第1天;卡培他滨1000 mg/m2,2次/d口服,第1～14天;28 d为1周期,连用2个周期后评价疗效.结果 25例可评价疗效,完全缓解(CR)1例,部分缓解(PR)7例,稳定(SD)5例,进展(PD)12例,客观有效率32.0%,中位疾病进展时间为5.3个月(3～9个月),1年生存率29.5%.所有患者均可评价毒副反应,主要为骨髓抑制、消化道副反应和神经毒性,均为可逆性.结论 L-OHP联合卡培他滨二线治疗晚期胃癌疗效肯定,毒副作用小,值得临床推广及进一步研究.
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