You Position: Home > Paper
A long follow-up study of relationship between gastric MALT lymphoma following Hp eradication and its bcl-10 nuclear expression
( views:247, downloads:16 )
- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1006-9801.2006.09.005
- Key Word:
- 胃黏膜相关淋巴组织淋巴瘤bcl-10;核表达;抗幽门螺旋杆菌治疗;随访研究
Abstract： 目的 探讨抗幽门螺旋杆菌(Hp)治疗胃黏膜相关淋巴组织(MALT)淋巴瘤的远期效果及bcl-10在肿瘤对抗Hp治疗的反应性判断中的意义.方法 选择12例Hp阳性胃MALT淋巴瘤,用免疫组化的方法检测肿瘤细胞bcl-10表达的情况,给予规范抗Hp治疗,并密切进行内窥镜随访.结果 在单纯抗Hp治疗后6例获得完全缓解(CR),无一例检测到bcl-10核表达.余6例未达CR的病例中4例检测到bcl-10核表达.提示瘤细胞存在bcl-10的核表达,证明肿瘤的发展已与Hp作用无关,也提示临床,目前抗Hp治疗并非此类患者的首选治疗方案.这12例单纯抗Hp治疗CR率为50%(6/12),中位随访时间13.5个月.抗Hp后获得CR中位时间1.5个月,最长为6个月.至今,CR持续中位时间为14个月,最长达2年.结论 抗Hp治疗可以使相当一部分胃MALT淋巴瘤患者获得CR,bcl-10核表达可能与肿瘤对抗Hp治疗不反应密切相关,但需进一步扩大样本量及延长随访时间证实.
- [1]Thiede C,Wundisch T,Neubauer B,etc.Eradication of Helicobacter pylori and stability of remissions in low-grade gastric B-cell lymphomas of the mucosa-associated lymphoid tissue: results of an ongoing multicenter trial.[C].2000.
- [2]刘冬梅,王晋芬,张建中.应用组织芯片技术研究bcl-10、TopoⅡα及Ki-67在MALT型淋巴瘤中的表达和意义[J].2005,(2).
- [3]A C, Wotherspoon,C, Ortiz-Hidalgo,M R, Falzon,etc.Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma.[J].1991,338(8776).
- [4]A.C. Wotherspoon,T.C. Diss,L. Pan,etc.Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori[J].1993,342(8871).
- [5]P, Isaacson,D H, Wright.Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma.[J].1983,52(8).
- [6]H, Liu,H, Ye,A, Dogan,etc.T(11; 18)(q21; q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10.[J].2001,98(4).
- [7]Peter G. Isaacson,Timothy C. Diss,Andrew C. Wotherspoon,etc.Long-term follow-up of gastric MALT lymphoma treated by eradication of H. pylori with antibiotics[J].1999,117(3).
- [8]M Stolte,S Eidt.Lymphoid follicles in antral mucosa: immune response to Campylobacter pylori?[J].1989,42(12).
- [9]Morgner A,Du MQ,Gunther A,etc.Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication.[J].2005,23(31).
- [10]Ho L,Du MQ,Hamoudi RA,etc.MALT lymphoma with t(14; 18)(q32; q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression.[J].2005,205(3).