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Cationic liposomes complexed to plasmids encoding endostatin and angiostatin inhibit lewis lung cancer in mice model
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1006-9801.2006.06.002
- Key Word:
- SA脂质体介导血管抑素;内皮抑素基因;Lewis肺癌小鼠移植瘤
Abstract： 目的观察SA脂质体介导血管抑素和/或内皮抑素基因对Lewis肺癌小鼠移植瘤生长、转移的抑制作用.方法建立C57BL/6j小鼠肺癌模型,30只荷瘤鼠随机分空白对照组,SA脂质体对照组,血管抑素基因(pAng)治疗组,内皮抑素基因(pEnd)治疗组,血管抑素和内皮抑素基因联合治疗组,每组6只.以SA脂质体介导,将血管抑素和/或内皮抑素基因直接注入移植瘤内,每周2次,共6周,每周测瘤体大小2次,6周末处死所有小鼠,观察瘤体大小变化、肺表面转移灶数、生存期等.结果各治疗组均能抑制肿瘤增长及肺内转移,与对照组比较有统计学意义(P＜0.01),小鼠活动能力、饮食、对外界刺激的反应能力均无明显改变,生存期明显长于对照组.结论SA脂质体介导血管抑素和/或内皮抑素基因治疗可有效地抑制Lewis肺癌移植瘤的生长、转移,生存期明显长于对照组.
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