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Toxic experimental study of Antineoplastic agents-Fotemustine
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1006-9801.2006.03.004
- Key Word:
- 福莫司汀注射液;安全性评价;家兔;豚鼠
Abstract： 目的对福莫司汀注射液进行安全性评价.方法采用福莫司汀注射液进行家兔耳缘静脉血管的刺激性试验及豚鼠的变态反应试验;体外观察福莫司汀注射液对兔红细胞悬液的溶血作用及有无红细胞凝聚作用.结果家兔耳缘静脉多次给药后,可见血管充血和血管外局限性出血,但未见血管壁明显的病理性改变,与溶剂对照组比较无统计学差异;对兔红细胞没有溶血作用和凝聚作用;在豚鼠致敏试验中,未见变态反应发生.结论福莫司汀注射液对血管无刺激性,属弱致敏性物质,也无溶血及红细胞凝聚现象.
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