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The morphologic changes of orthotopic rat bladder tumor induced by non-invasive pelvic cavity regional moderate hyperthermia
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1006-9801.2006.03.002
- Key Word:
- 热疗;大鼠;膀胱肿瘤
Abstract： 目的研究亚高温盆腔区域热疗致大鼠膀胱肿瘤形态学改变.方法制备原位的大鼠膀胱肿瘤动物模型,用内生场热疗系统从体外加热大鼠盆腔至41℃,热疗后对肿瘤进行病理研究.结果电镜观察短期组有早期凋亡细胞出现;长期组凋亡细胞和凋亡小体多见.肿瘤细胞HSP70表达率短期组中热疗组均高于对照组,差异有统计学意义(P＜0.01),而长期组中差异无统计学意义.PCNA LI热疗组均低于对照组,差异有统计学意义(P＜0.01).AI热疗组均高于对照组,差异有统计学意义(P＜0.01).结论亚高温盆腔区域热疗抑制肿瘤细胞增生,诱导凋亡,长期热疗未导致热耐受.
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