You Position: Home > Paper
Expression of microvessel density marked with Endoglin in gastric cancer and precancerous lesion
( views:200, downloads:0 )
- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1006-9801.2006.02.005
- Key Word:
- 胃癌;癌前病变;Endoglin标记;微血管密度
Abstract： 目的研究Endoglin标记的微血管密度计数(MVD)与胃癌发生发展的关系.方法采用免疫组织化学法检测60例胃癌和56例胃癌癌前病变组织中Endoglin标记的微血管密度计数.结果Endoglin标记的MVD在胃癌发生过程中增加显著,其表达强度与胃癌临床分期、淋巴结转移、细胞分化程度有关,与胃癌患者性别、年龄无关.结论Endoglin与胃癌的发生发展有关,Endoglin标记的MVD检测有可能成为胃癌诊断、病情监测及预后判断的一项有价值的指标.
- [1]Schimming Ronald,Marme Dieter.Endoglin (CD105) expression in squamous cell carcinoma of the oral cavity.[J].2002,24(2).
- [2]S, Kumar,A, Ghellal,C, Li,etc.Breast carcinoma: vascular density determined using CD105 antibody correlates with tumor prognosis.[J].1999,59(4).
- [3]B K, Seon,F, Matsuno,Y, Haruta,etc.Long-lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin.[J].1997,3.
- [4]Stattin P,Lissbrant IF,Bergh A,etc.Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer.[J].2002,51(4).
- [5]Daniel W. Miller,Wolff Graulich,Bernadett Karges,etc.Elevated expression of endoglin, a component of the TGF-β-receptor complex, correlates with proliferation of tumor endothelial cells[J].1999,81(4).
- [6]B, Bodey,B, Bodey,S E, Siegel,etc.Over-expression of endoglin (CD105): a marker of breast carcinoma-induced neo-vascularization.[J].1900,18(5A).