You Position: Home > Paper
The expression of COX-2 and its relationship to the apoptosis and proliferation in colorectal carcinoma
( views:231, downloads:0 )
- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1006-9801.2005.05.004
- Key Word:
- 大肠癌;环氧化酶-2;细胞增生抗原;细胞凋亡
Abstract： 目的探讨大肠癌中环氧化酶-2(cyclooxygenase-2,COX-2)表达及其与癌细胞增生和凋亡的关系.方法采用免疫组织化学法检测60例大肠癌、20例大肠腺瘤和20例癌旁正常大肠黏膜中COX-2和PCNA的表达,并采用TUNEL法检测原位细胞凋亡水平.结果大肠癌组织中COX-2阳性表达、PI及AI均显著高于大肠腺瘤及正常大肠黏膜组织(P＜0.05);COX-2的高表达与大肠癌肿瘤大小、淋巴结转移和临床分期有关,与肿瘤生长部位、分化程度无关.COX-2阳性大肠癌组中PI高于COX-2阴性大肠癌组,AI低于COX-2阴性大肠癌组(P＜0.05).结论COX-2的过度表达可促进大肠癌细胞增生、抑制细胞凋亡,在大肠癌的发生、发展过程中起着重要的作用.
- [1]Tsujii M,Reese J,Williams CS,etc.Host cyclooxygenase-2 modulates carcinoma growth (see comments)[J].2000,105(11).
- [2]Fosslien E.Molecular pathology of cyclooxygenase-2 in neoplasia.[J].2000,30(1).
- [3]M C, Cummings,C M, Winterford,N I, Walker.Apoptosis.[J].1997,21(1).