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The thymic recent output function in patients with acute promyelocytic leukemia
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1006-9801.2005.03.003
- Key Word:
- TRECs;胸腺近期输出功能;白血病;实时定量PCR
Abstract： 目的了解急性早幼粒细胞白血病(APL)患者T细胞受体重排删除DNA环(TRECs)的含量,从而了解患者胸腺近期输出naive T细胞的水平.方法利用实时定量PCR(TaqMan)方法检测9例APL患者和14例正常人外周血单个核细胞(PBMC)TRECs的水平,并根据外周血中CD3阳性率计算CD3细胞中TRECs水平.结果正常人TRECs拷贝数为(4.10±3.65)/1000PBMC和(6.36±5.28)/1000CD+3细胞,APL患者TRECs拷贝数为(0.13±0.22)/1000PBMC和(0.77±1.60)/1000CD+3细胞,与正常人相比均有显著性差异(P=0.0004,p=0.0005).结论率先报道了APL患者胸腺近期输出naive T细胞功能明显降低的情况.
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