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cDNA microarray screening biomarkers which simultaneously participate in different carcinogenesis progression in lung adenocarcinoma
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1006-9801.2005.03.001
- Key Word:
- 肺肿瘤;基因表达;基因芯片
Abstract： 目的探讨同时参与肺腺癌不同癌变进程的基因群,以期进一步筛选出肺腺癌的分子靶标.方法选取术后临床分期为Ⅰ、Ⅱ、Ⅲ期的肺腺癌组织标本共10例为实验组,相应的癌旁组织10例为对照组.与含13824个基因的基因芯片进行杂交,最后结合分期和临床预后对海量数据进行数据挖掘.在不同分期及不同预后的标本中均差异表达的基因即为入选基因.结果10例肺腺癌标本共差异表达基因119条,其中,含已报道与肺癌相关的基因26条,尚未报道与肺癌相关的基因46条,完全未知功能的新基因47条.结论119条基因是肺腺癌发生、发展过程中的重要分子标记,是肺腺癌分子靶的候选基因.
- [1]Everett AD,Mao L,Feng L,etc.Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-small-cell lung cancer.[J].2004,22(16).
- [2]Schluns K,Denkert C,Yongwei Y,etc.CD24 is an independent prognostic marker of survival in nonsmall cell lung cancer patients.[J].2003,88(2).
- [3]Abe T,Curiel DT,Terada M,etc.Efficient gene transduction by RGD-fiber modified recombinant adenovirus into dendritic cells.[J].2001,92(3).
- [4]Randall N.Knibbs,Lloyd M.Stoolman,Keishi Tanigawa,etc.Tumor-Specific Responses in Lymph Nodes Draining Murine Sarcomas Are Concentrated in Cells Expressing P-Selectin Binding Sites[J].2001,167(6).
- [5]Tomita K,Shimizu E,Osaki M,etc.MCM2 and Ki-67 expression in human lung adenocarcinoma: prognostic implications.[J].2004,71(4).