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Detection of apoptotic inhibitor gene survivin in esophageal cancer by real-time fluorescence quantitative PCR and its clinical significance
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1006-9801.2005.02.005
- Key Word:
- 食管癌;不典型增生;原位癌;荧光定量PCR法;凋亡抑制基因Survivin
Abstract： 目的探讨食管癌发生发展过程中凋亡抑制基因Survivin的表达及其与食管癌病理特征的关系.方法采用实时荧光定量PCR法,检测Survivin在78例食管病变患者胃镜标本中正常食管黏膜、不典型增生、原位癌及浸润癌组织的表达强度.结果Survivin在正常食管黏膜、不典型增生、原位癌及浸润癌组织中呈渐进性高表达.结论Survivin与食管癌的发生、发展密切相关,实时荧光定量PCR法检测食管癌中Survivin基因,可作为食管肿瘤早期诊断的可靠方法.
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