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The expression of P-gp, GST- π and Topo Ⅱ in breast cancer and their clinical significance
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1006-9801.2005.01.005
- Key Word:
- 乳腺肿瘤;多药耐药;P-糖蛋白;谷胱甘肽-S-转移酶-π;拓扑异构酶Ⅱ
Abstract： 目的探讨多药耐药基因蛋白P-糖蛋白(P-gp)、谷胱甘肽-S-转移酶-π(GST-π)及DNA拓扑异构酶Ⅱ(TopoⅡ)在乳腺癌中的表达及其临床意义.方法用免疫组化S-P法对60例未经抗肿瘤治疗的原发乳腺癌检测P-gp、GST-π及TopoⅡ蛋白表达.结果乳腺癌组织中P-gp、GST-π和TopoⅡ表达率分别为37.1%、66.7%和55.0%.P-gp、TopoⅡ的表达与组织学分级相关(P＜0.05),组织学分级越高阳性率越高.P-gp的表达与淋巴结是否转移存在相关性(P＜0.05),淋巴结转移者阳性率高.结论化疗前检测P-gp、GST-π及TopoⅡ的耐药基因蛋白,对判断乳腺癌的预后及指导化疗有一定的价值.
- [1]余震,龚建平.肿瘤抑制基因和耐药基因在肿瘤化疗中的应用进展[J].2004,(8).
- [2]Kondo T,Oka M,Kohno S,etc.Overexpression of glutathione S-transferase pi enhances the adduct formation of cisplatin with glutathione in human cancer cells.[J].1999,31(6).
- [3]Chow H, Lee.Reversing agents for ATP-binding cassette (ABC) transporters: application in modulating multidrug resistance (MDR).[J].2004,4(1).
- [4]Franziska Joncourt,Katharina Buser,Hansjörg Altermatt,etc.Multiple Drug Resistance Parameter Expression in Ovarian Cancer[J].1998,70(2).
- [5]Guinee Donald G.,Holden Joseph A.,Benfield John R.,etc.Comparison of DNA topoisomerase II\u03b1 expression in small cell and nonsmall cell carcinoma of the lung: In search of a mechanism of chemotherapeutic response[J].1996.
- [6]Jean-Louis Pujol,Joëlle Simony,Véronique Gautier,etc.Immunohistochemical study of P-glycoprotein distribution in lung cancer[J].1993,10(1-2).
- [7]Avril A,Picot V,Robert J,etc.DNA topoisomerase IIalpha expression and the response toprimary chemotherapy in breast cancer.[J].2003,89(4).
- [8]Endicott J A,Ling V.The Biochemistry of P-Glycoprotein-Mediated Multidrug Resistance[J].1989.
- [9]Huang J,Bay BH,Tan PH,etc.Prognostic significance of glutathione S-transferase-pi in invasive breast cancer.[J].2003,16(6).