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THE EFFECTS AND ITS CLINICAL SIGNIFICANCE OF THE EXPRESSION OF MMP-7 OF LIFEIN ON RECTAL CANCER
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1006-9801.2004.06.006
- Key Word:
- 力尔凡;直肠癌;MMP-7;浸润和转移
Abstract： 目的:评价力尔凡对直肠癌MMP-7表达的影响及临床意义.方法:将32例低位直肠癌患者随机分为力尔凡治疗组与对照组,治疗组在术前瘤体内注射力尔凡后接受手术治疗,对照组仅接受手术治疗,并通过免疫组化法分别检测两组MMP-7的表达.结果:MMP-7在对照组与力尔凡治疗组的表达明显高于对照组,分别为85.7%,68.7%,有显著性差异;对照组中DukesB期和C期MMP-7的表达有显著性差异.结论:术前瘤体内注射力尔凡,可明显降低直肠癌MMP-7的表达,在Dukes C期比B期更明显.
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