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THE EXPRESSION OF NUCLEAR FACTOR- κB AND CYCLOOXYGENASE 2 IN LARGE BOWEL CARCINOMA AND THEIR RELATION TO ANGIOGENESIS
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1006-9801.2004.06.003
- Key Word:
- 大肠癌;核因子-κB;环氧合酶2;微血管密度
Abstract： 目的:探讨核因子-κ B(NF-κ B)和环氧合酶2(Cox-2)在大肠癌中的表达及其与微血管密度(MVD)之间的关系.方法:应用免疫组化SP法检测72例大肠癌组织NF-κB、Cox-2和MYD的阳性表达.结果:大肠癌组织的NF-κ B和Cox-2的阳性表达率明显高于正常结肠黏膜.大肠癌组织NF-κ B的阳性表达和肿瘤淋巴结转移、肝转移以及Dukes分期密切相关.Cox-2的阳性表达和大肠癌的局部浸润深度、淋巴结和肝转移以及Dukes分期均具有显著相关性.NF-κB阳性表达的大肠癌组织中Cox-2的阳性表达率明显高于NF-κ B表达阴性者.NF-κ B阳性表达组或Cox-2阳性表达组大肠癌MVD数量显著高于NF-κB阴性表达组或Cox-2阴性表达组.结论:NF-κB和Cox-2参与了大肠癌的发生、浸润和转移.它们在大肠癌的血管形成中起重要作用.
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