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EXPRESSION OF p21WAF1,PCNA IN CHILDREN NEPHROBLASTOMA AND ITS CLINICAL SIGNIFICANCE
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1006-9801.2004.05.004
- Key Word:
- 肾母细胞瘤;细胞周期调控;PCNA;p21WAF1;免疫组织化学
Abstract： 目的:探讨p21WAF1和增生细胞核抗原(proliferating cell nuclear antigen,PCNA)的检测在小儿肾母细胞瘤的诊断和预后评估方面的应用价值.方法:对1985年-2002年的32例经病理证实的小儿肾母细胞瘤石蜡标本,用免疫组织化学的方法检测p21WAF1和PCNA的表达水平,并评价它们的临床意义.结果:PCNA和p21WAF1的表达均与肾母细胞瘤组织学分型、临床肿瘤分期和淋巴结转移相关;p21WAF1表达指数(p21WAF1expressionindex,PI)和PCNA表达指数(PCNA expression index,PCI)呈负相关,表明p21WAF1的高表达可能对细胞增生周期有抑制作用.结论:本研究从细胞周期调控的角度为推测肾母细胞瘤发生、诊断和预后评估提供了新的思路.
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