You Position: Home > Paper
CORRELATION ANALYSIS ON THE TUMOR ANGIOGENESIS AND GLUTATHIONE S-TRANSFERASE-π IN BLADDER TRANSITIONAL CELL CARCINOMA
( views:171, downloads:0 )
- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1006-9801.2004.05.003
- Key Word:
- 膀胱癌;血管内皮生长因子;微血管密度;谷胱甘肽-S-转移酶-π
Abstract： 目的:探讨膀胱癌肿瘤血管生成与谷胱甘肽-S-转移酶-π(GST-π)的相互关系.方法:将82例膀胱癌手术切除标本分成原发组和复发组,应用S-P免疫组化法检测GST-π、血管内皮生长因子(VEGF)、微血管密度(MVD)的表达情况,将数据作统计学处理.结果:复发组的膀胱癌MVD、VEGF、GST-π指数明显高于原发组(P<0.05或P<0.01),VEGF和GST-π存在正相关性(P<0.01),MVD和GST-π存在正相关性(P<0.01).结论:膀胱癌VEGF高表达在肿瘤血管生成中起重要作用,VEGF和MVD与GST-π在诱导膀胱癌耐药方面可能存在着协同机制,VEGF、MVD与GST-π在膀胱癌中的联合检测对判断肿瘤的生物学行为和预后及化疗药物的敏感性预测有重要意义.
- [1]Y, Ogura,K, Sato,T, Kato,etc.[Immunohistochemical analysis of expression of angiogenic factors and tumor angiogenesis in superficial bladder cancer].[J].1998,89(5).
- [2]H, Shen,L, Kauvar,K D, Tew.Importance of glutathione and associated enzymes in drug response.[J].1997,9.
- [3]H T, Zhang,P, Craft,P A, Scott,etc.Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells.[J].1995,87.
- [4]N S, Waleh,M D, Brody,M A, Knapp,etc.Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker.[J].1995,55.
- [5]J, Folkman.What is the evidence that tumors are angiogenesis dependent?[J].1990,82(1).
- [6]Hollingsworth HC,Kohn EC,Steinberg SM,etc.Tumor angiogenesis in advanced stage ovarian carcinoma.[J].1995,147(1).
- [7]H F, Dvorak,L F, Brown,M, Detmar,etc.Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.[J].1995,146.
- [8]M, Volm,R, Koomagi,M, Kaufmann,etc.Microvessel density, expression of proto-oncogenes, resistance-related proteins and incidence of metastases in primary ovarian carcinomas.[J].1996,14(3).