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THE EXPRESSION AND SIGNIFICANCE OF THE MIDKINE IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1006-9801.2004.05.002
- Key Word:
- 食管癌;MK;免疫组织化学
Abstract： 目的:研究中期因子(midkine,MK)蛋白在食管癌中的表达情况,并探讨MK与其生物学行为的关系.方法:采用免疫组织化学S-P法,检测45例食管癌患者手术切除标本、10例正常食管黏膜组织及配对癌旁组织MK蛋白的表达情况.结果:MK在食管癌中为高表达(表达率为77.8%),与食管癌的组织分化程度、癌组织浸润深度有统计学意义上的相关性,而与肿瘤部位及淋巴结转移无统计学意义上的相关性.结论:MK与食管癌的形成及肿瘤分化程度、浸润深度有关.
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