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EXPRESSION OF TELOMERASE REVERSE TROMSCRIPTASE AND CA125 IN OVARIAN EPITHELIAL TUMORS
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1006-9801.2004.04.005
- Key Word:
- 卵巢肿瘤;端粒酶;CA125;TRT;免疫组化
Abstract： 目的:探讨端粒酶反转录酶(TRT)与CA125在卵巢上皮性肿瘤组织中的原位表达及临床意义.方法:收集93例卵巢上皮性肿瘤(良性47例、交界性15例、恶性31例),应用免疫组织化学S-P法检测肿瘤组织中TRT及CA125的原住表达,将结果进行统计学分析.结果:TRT的表达在良性(17.02%,8/47)和交界性(46.67%,7/15)以及恶性(90.32%,28/31)间的差异均有显著性意义(P＜0.01);CA125的表达在良性(23.40%,11/47)和恶性(67.74%,21/31)间的差异有显著性意义(P＜0.01),TRT的表达在浆液性肿瘤与黏液性肿瘤之间差异无显著性意义(P＞0.05);CA125在各组浆液性肿瘤均明显高于黏液性肿瘤组,相比较差异有显著性意义(P＜0.05);TRT和CA125在浆液性肿瘤的表达有一致性,相关性分析有显著性相关(P＜0.01),在黏液性肿瘤中表达不相关(P＞0.05).结论:TRT和CA125的表达与卵巢上皮组织肿瘤的良恶性有关,尤其在卵巢浆液性肿瘤中TRT酶的活性与CA125呈正相关,二者的共同检测对诊断卵巢上皮组织肿瘤的类型和恶性程度有重要的临床意义.
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