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RESEARCH ON THE RELATIONSHIP BETWEEN NEUROPEPTIDE y AND HUMAN PITUTARY ADENOMAS
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1006-9801.2004.04.002
- Key Word:
- NPY;垂体腺瘤;相关性
Abstract： 目的:探讨垂体腺瘤患者血浆NPY与垂体腺瘤之间的相关关系.方法:采取82例垂体腺瘤患者及20例对照组术前、术后空腹静脉血各3mL,对其进行血浆NPY的放射免疫测定分析.结果:NPY在垂体腺瘤组与对照组中血浆含量明显不同,垂体腺瘤组血浆NPY含量高于对照组;全组垂体腺瘤手术后血浆NPY的含量明显下降,而对照组不明显.结论:NPY参与了垂体腺瘤患者下丘脑-垂体轴许多激素的调节,可能与垂体腺瘤的发生有关.
- [1]P J, Larsen,K E, Jukes,H S, Chowdrey,etc.Neuropeptide-Y potentiates the secretion of vasopressin from the neurointermediate lobe of the rat pituitary gland.[J].1994,134(4).
- [2]Donald R. Gehlert,Susan L. Gackenheimer,William R. Millington,etc.Localization of neuropeptide Y immunoreactivity and [125I]peptide YY binding sites in the human pituitary[J].1994,15(4).
- [3]Tatemoto Kazuhiko,Carlquist Mats,Mutt Viktor.Neuropeptide Y\u2014a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide[J].1982.
- [4]Eric Grouzmann,Jean-Paul Deruaz,Fulgencio Gomez,etc.Immunolocalization of neuropeptide Y in human pituitary tumours[J].1998,75–76(1).
- [5]P M, Jones,M A, Ghatei,J, Steel,etc.Evidence for neuropeptide Y synthesis in the rat anterior pituitary and the influence of thyroid hormone status: comparison with vasoactive intestinal peptide, substance P, and neurotensin.[J].1989,125(1).
- [6]Schuster S,Dotsch J,Rascher W,etc.Gene expression of adrenomedullin, leptin, their receptors and neuropeptide Y in hormone-secreting and non-functioning pituitary adenomas, meningiomas and malignant intracranial tumours in humans.[J].2001,27(3).
- [7]Byrne J M,Jones P M,Hill S F,etc.Expression of messenger ribonucleic acids encoding neuropeptide-Y, substance-P, and vasoactive intestinal polypeptide in human pituitary.[J].1992.
- [8]M E, de Quidt,P C, Emson.Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system--II. Immunohistochemical analysis.[J].1986,18(3).