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Cyclooxygenase-2 Expression in Cervical Cancer:Its Relationship to HPV Infection
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1006-9801.2004.03.006
- Key Word:
- 环氧合酶-2;宫颈癌;人乳头瘤病毒
Abstract： 目的:探讨环氧合酶-2(COX-2)在宫颈癌发生发展中的作用,分析COX-2与宫颈癌中HPV16感染之间的关系.方法:收集46例宫颈癌组织作为实验组,31例健康的宫颈组织作为对照组.用免疫组化方法检测各组的COX-2表达水平.用PCR方法检测宫颈癌组的HPV16 DNA.结果:COX-2在宫颈癌组织中有较高表达;COX-2在宫颈癌组织中表达与年龄、临床分期、组织分化程度、浸润深度之间均无相关性,而与淋巴结转移有显著相关性;宫颈癌组织中HPV16 DNA阳性率为56.52%(26/46),在COX-2表达阳性的宫颈癌组织中,HPV16 DNA阳性组的染色分值明显高于HPV16DNA阴性组.结论:宫颈癌的发生发展中有COX-2的参与,并且COX-2与宫颈癌的转移密切相关.宫颈癌中COX-2高表达与HpV16感染可能有一定的相关性.
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