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Prognostic Value of HSP70 and bcl-2 Protein in Cervical Carcinoma Radiotherapy
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1006-9801.2004.03.004
- Key Word:
- 宫颈癌;HSP70;bcl-2;放疗;免疫组织化学
Abstract： 目的:探讨HSP70、bcl-2在宫颈癌放疗中的表达及其与预后的关系.方法:采用免疫组织化学法对常规甲醛固定,石蜡包埋的宫颈浸润性鳞癌64例标本,分别检测癌组织中放疗前HSP70、bcl-2蛋白的表达,并对其进行定期随访.结果:HSP70在宫颈癌细胞中过表达,其表达与病理分级呈正相关(P＜0.01);与放疗后近期疗效呈正相关(P＜0.01);高表达组与低表达组相比1 a、3 a无病生存期显著降低(P＜0.01);bcl-2蛋白表达与病理分级呈负相关(P＜0.05);不表达组放疗后肿瘤消退显著(P＜0.01);其1 a、3 a无病生存期显著低于阳性表达组(P＜0.05).结论:HSP70表达水平可以作为宫颈癌细胞增生、分化及远期疗效判定的指标;bc1-2蛋白表达可作为远期疗效判定的标志.
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